Personal+Genomics+Behind+Endometriosis+Methods

=__Methods __=

In this personal genomic study of endometriosis, various sources were used to gather information about the personal genomics correlated to the disease risk. Companies, such as 23 and me, were used in this study to discover what genes and SNPs of interest are important when assessing disease risk. The company, 23 and me, specifically looks at variant markers on specific genes in the human genome that may be correlated with a women’s disease risk for endometriosis. Some of the other online resources used for this research study were genetic databases such as GWAS gene catalog, gene world site, 1000 genomes, Ensembl, HapMap website, DrugBank, and PharmGKB. In addition to online programs, personal genomics data also came from primary research articles.

__The HapMap Program__:

This website is a great tool for researchers because it provides so much detailed information about specific genes and SNP variants.

To use the HapMap program go to the following URL, [|http://hapmap.ncbi.nlm.nih.gov/cgi-perl/gbrowse/hapmap28_B36/#search].

__Searched terms__:

CHD5 gene WNT4 gene ESR1 gene CDKN2BAS1 gene

Date Acessed: March 2016

__Ensembl Program__:

Ensembl program allows personal genomic researchers to learn more information about the variants of genes seen in populations worldwide.

To use the Ensembl program go to the following URL, [].

Searched terms: <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> CHD5 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> WNT4 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> ESR1 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> CDKN2BAS1 gene

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">Date Acessed: <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> March 2016

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">__Gene World Mapping Program:__

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">Gene World Mapping is a great site for genomic resreachers looking to obtain a visual representation of the populations of people affected by a certain disease. The information is based on SNP data.

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">To access Gene World Mapping, go to the following URL: [].

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">Searched terms: <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> CHD5 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> WNT4 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> ESR1 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> CDKN2BAS1 gene

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">Only marker variant available for endometriosis on the Gene World Mapping was Rs 10965235.

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">Date Acessed: <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> March 2016

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">__GWAS Catalog Program__:

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">The GWAS catalog is an online database of gene and SNP information. A genomic researcher could use this site to gather a lot information on their genes of interest.

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">To access the GWAS catalong, go to the following URL: https://www.ebi.ac.uk/gwas/.

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">Searched terms: <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> CHD5 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> WNT4 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> ESR1 gene <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;"> CDKN2BAS1 gene

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%; line-height: 1.5;">Date Acessed: <span style="font-family: Arial,Helvetica,sans-serif; font-size: 150%;">March 2016

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