Gene+and+Protein

Gene and Protein **Gene**  The gene ATP7B is located on 13q14.3 with a total genomic length of 80kb and 21 exons, that encodes for the production of P type ATPase, a transmembrane copper transporting protein that is 1465 amino acids long. The protein ATPase is synthesized in the endoplasmic reticulum then it is confined on the trans Golgi network of hepatocytes (Todorov, 2016). Various levels of ATPase are also noticeable in the brain, kidneys, and lungs.  This image was obtained from UCSC genome database. ATP7B is located on chromosome 13. It is represented by the red line. Retrieved from []

Protein
The ATP7B protein is a part of the P-type ATPase superfamily which consists of 11 classes. More specifically, P-type ATPase of class IB (PIB) consists of ATP7A and ATP7B. They are responsible for the transportation of copper and other heavy metal ions across biological membranes. The structure of the protein includes several domains: actuator domain (A-domain), phosphorylation domain (P-domain), nucleotide-binding domain (N-domain), and the metal-binding domain (M-domain) which are composed of eight transmembrane-spanning helices (Chen, 2015). This shows the complexity of the core structures of ATP7B protein and that it is highly conserved.

Figure 1: This image of the protein of ATP7B is retrieved from NCBI. It helps in the visualization of the structure of the protein explained earlier.

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