Stacia+Phylogenetic+Tree


 * Maximum Likelihood Phylogenetic Tree : SH2B3 Protein in Celiac Disease **

This phylogenetic tree shows comparisons of similar genes across many different organisms and how closely related different organisms may be. In this particular case, the SH2B3 protein found in //Homo sapiens// is being compared to similar genes found in //Pan troglodytes//, //Bos taurus//, //Mus musculus//, and //Danio rerio.//



Figure. Molecular Phylogenetic anaylsis by Maximum Likelihood method The evolutionary history was inferred by using the Maximum Likelihood method based on the JTT matrix-based model [1]. The tree with the highest log likelihood (-2190.8400) is shown. The percentage of trees in which the associated taxa clustered together is shown next to the branches. Initial tree(s) for the heuristic search were obtained automatically as follows. When the number of common sites is < 100 or less than one fourth of the total number of sites, the maximum parsimony method was used; otherwise BIONJ method with MCL distance matrix was used. The tree is drawn to scale, with branch lengths measured in the number of substitutions per site. The analysis involved 7 amino acid sequences. All positions containing gaps and missing data were eliminated. There were a total of 315 positions in the final dataset. Evolutionary analyses were conducted in MEGA5 [2].

1. Jones DT, Taylor WR & Thornton JM (1992) The rapid generation of mutation data matrices from protein sequences. Computer Applications in the Biosciences 8: 275-282.

2. Tamura K, Dudley J, Nei M & Kumar S (2007) MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Molecular Biology and Evolution 24:1596-1599.

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