More+Breast+Cancer+Results

__ Kinds of Maps __
Breast Cancer is not just a local disease. Viewing Erik Corona's Genetic Risk World Map shows the overall spread of Breast Cancer throughout history.

A gene linked to Breast Cancer is PIK3CA. By using the STRING database, a diagram creates a 'map' for known and predicted interactions between other proteins between the gene of interest.



All cancers come from DNA abnormalities or mutations, which allow their cells to grow rapidly or not die off as intended. COSMIC has all known somatic mutations that deal with cancer. The website is linked to other National databases where articles and other genomic information can be accessed.



__ Drugs __
When discussing genomics and breast cancer, another piece of the puzzle are drug therapies used and their predicted targets and modes of passage through the body. It is important for researchers to know the mechanism of action for each medication. Genetic variants have been found to have a role in dosing amounts, efficacy, and may even cause adverse effects that the normal population would not have. By understanding the gene and protein variations breast cancer patients have, will create personalized treatments.



Below is a representation of how a common breast cancer drug, Tamoxifen, gets metabolized through the liver and can then inhibit the cancer cells to take in the estrogen it requires to continue to grow.

Tamoxifen Pathway, Pharmakogenomics: []



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