Celiac+Disease



Celiac Disease 

By: Stacia Stickney University of New Hampshire Manchester, NH svy3@unh.edu

Celiac Disease Background Information

Click here:Research to learn more about recent research that has been done on Celiac Disease

Click here: BLASTp to learn more about the SH2B3 gene in the BLASTp program

Click here: Phylogenetic Tree to view a Phylogenetic Tree for the SH2B3 gene

Annotated Bibliography

1. Bertini, I., et al. (2009). The Metabonomic Signature of Celiac Disease. Journal of Proteome Research. 8, 170-177.

This article was my primary article and was used for my research in a specific study. The study of the metabonomic signature of Celiac Disease was discussed in detail and all results were summarized in the "research" section of this project. All data figures came from this article as well as some background information about Celiac Disease.

2. Fasano, A. (August 2009). Surprises from Celiac Disease. Scientific American. 54-61.

This article was used for background information as well as some diagnosis and treatment techniques.

3. Galvan, J.A. (November 2009). Silent Celiac Disease in a Cohort of Healthy Adults. Autoimmunity. 42(8): 705-708.

This article was used to background information and research purposes. This article gave a second study that was recently done and allowed me to further expand my knowledge on the disease and its possible causes, treatments, and data. This study took place in Cuba and the Caribbean region.

Bioinformatics Tools 1. BLASTp- Basic Local Alignment Search Tool was used to find the similarities and differences among different species using the same amino acid sequence.

2. Geneius- This program was used to help align the SH2B3 protein that is found in many species. Homo Sapiens were paired against its homologs and and alignment was done of the similar regions of the protein.

3. MEGA- This program was used to further align the proteins for the homologs and create five different Phylogenetic trees from the information. The Phylogenetic trees could then be exported to use in this project. 4. NCBI- This program was used to search Celiac Disease as well as the SH2B3 protein. Much of the background information and research was found from this data base.