PC+Primary+Research

The primary research article that I focused on was “The G48E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial”. This research was done to compare G48E mutation frequency among different ethnicities from various geographic regions to find out the risk of developing Prostate Cancer. The HOXB13 is part of large group of transcription factors called homeobox protein family. This protein acts as a tumor suppressor, stopping cells from growing and dividing uncontrollably. The HOXB13 gene mutations associated with prostate cancer alter MEIS of the HOXB13 protein which can lead to impaired function. The G48E mutation mediates the binding of HOXB13. This is located in chromosome 17. Attached here is PDF of my article

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