Fragile-X;+Does+Severity+Differ+Based+Upon+Gender?

__ How does gender affect the expression of Fragile-X Syndrome? __
Fragile-X Syndrome is an X linked disorder. Due to being linked to the X chromosome, this disorder will more heavily impact males. Men and Women contain different sex chromosomes; Men are XY while Women are XX. Males have a greater risk of inheriting this disease from their mothers, as they only have one X chromosome while the Y is inherited from their father. Females are able to be carriers of the disorder and have less of a chance to receive it than males do. Females do still exhibit the same disorder as male when both X chromosomes contain the mutation.



__Are there any other disorders associated with this inheritance pattern? __
Yes, premutation carriers of this disorder are at risk of premature ovarian failure and the fragile X-associated tremor/ataxia syndrome (Garber, 2008).

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