Effects+of+Alzheimer's+Disease

=**What Are The Effects of Alzheimer’s disease**= ====When APP is not functioning correctly (due to cleavage), Aβ takes its place and the result is senile plaques forming between the dendrites in the brain. Neuron synapses are responsible for sending electrical signals to the brain and throughout the body. The disruption in the neuron synapses due to the decrease in myelin and plaque formation affects the connection between then left posterior cingulate gyrus and the left superior parietal lobe.====

====ApoE is also associated with the monitoring Aβ, which if not removed, causes senile plaques in the brain. The plaques form due to ApoE being unable to monitor the formation of Aβ oligomers and the removal of them from the brain. In the ε4 allele, Aβ oligomer levels are 2.7 times greater then the levels in ε3 (Hashimoto et al., 2012). The formation of the Aβ oligomers was found to originate inside an individual due to the ApoE gene variations (ε4 and ε3) and not something caused by the outside environment (Hashimoto et al., 2012; Liu, Kanekiyo, Xu, & Bu, 2013). The cognitive decline associated with the ApoE gene is the result of ApoE not regulating the Aβ oligomers causing the formation of plaques between the dendrite of axons in the brain.====

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