CNL;+Primary+Research

The results from this study found a correlation between the //ASXL1// and //CSF3R// mutations commonly found in Chronic Neutrophilic Leukemia (CNL). This study also compared the different mutations in each gene. //CSF3R// had one common mutation, T6181 found in 11 of the 14 patients, while other mutations in genes like //SETBP1// and //CALR// were not as common in patients. The survival rate of patients with mutations in both //CSF3R// and //ASXL1// genes was significantly lower than the survival rate of patients with a mutation in only //CSF3R//.

The data from this study suggest that the //CSF3R// gene (more specifically, the T6181 mutation) is the most common mutation associated with CNL. From this, the data gathered on the //CSF3R// gene will be the primary focus of this experiment.



The findings from this study identify one common mutation in the //CSF3R// gene. The T618I mutation is a deletion in exon 14. In 13 patients with CNL, 14 mutations in the //CSF3R// gene were identified, 10 being the T618I mutation. Mutations in this gene were screened using PCR. The //SETBP1// gene was also investigated, and mutations were screened using PCR and Sanger sequencing. Six patients had one or more mutation in the //SETBP1// gene, 4 of which also had the T618I mutation in //CSF3R//.



The data from this study were used to identify the //SETBP1// gene for genomic analysis. There were only six patients with a mutation in this gene, but were not the only mutation in a WHO-defined patient.



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