AJT+REferences

=References=

Bosler, D., Mattson, J., & Crisan, D. (2006). Phenotypic heterogeneity in patients with homozygous prothrombin 20210AA genotype: A paper from the 2005 william beaumont hospital symposium on molecular pathology. //The Journal of Molecular Diagnostics,// //8//(4), 420-425. doi:10.2353/jmoldx.2006.060014

Ceelie, H., Riel, C. C. S., Bertina, R. M., & Vos, H. L. (2004). Coagulation G20210A is a functional mutation in the prothrombin gene; effect on protein levels  and 3′-end formation. //Journal of Thrombosis & Haemostasis//, 2(1), 119-127. doi:10.1111/j.1538-7836.2003.00493.x

Colucci, M., Binetti, B. M., Tripodi, A., Chantarangkul, V., & Semeraro, N. (2004). Hyperprothrombinemia associated with prothrombin G20210A mutation  inhibits plasma fibrinolysis through a TAFI-mediated mechanism. //Blood//, 103(6), 2157-2161.  Retrieved from @http://search.ebscohost.com.libproxy.unh.edu/login.aspx?direct=true&db=cmedm&AN=14630828&site=eds-live

Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. 1987;26:6165–6177.

Drummond AJ, Ashton B, Buxton S, Cheung M, Cooper A, Duran C, Field M, Heled J, Kearse M, Markowitz S, Moir R, Stones-Havas S,Sturrock S, Thierer T, Wilson A (2011) //Geneious v5.5,// Available from []

Lane, D. A., & Grant, P. J. (2000). Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. //Blood//, 95(5), 1517-1532.  Retrieved from @http://search.ebscohost.com.libproxy.unh.edu/login.aspx?direct=true&db=cmedm&AN=10688804&site=eds-live

Moore, J. H., & Williams, S. M. (2009). Epistasis and its implications for personal genetics. //The American \Journal of Human Genetics,// //85//(3), 309-320. doi:10.1016/j.ajhg.2009.08.006

Ng, P. C., Murray, S. S., Levy, S., & Venter, J. C. (2009). An agenda for personalized medicine. //Nature,// 461(7265), 724-726. doi:10.1038/461724a

Tamura K, Peterson D, Peterson N, Stecher G, Nei M, and Kumar S (2011) MEGA5: Molecular Evolutionary Genetics Analysis using Maximum  Likelihood, Evolutionary Distance, and Maximum Parsimony Methods. Molecular Biology and Evolution (submitted).  (Publication PDF at __[] __)  Thrombin pathway. Retrieved from @http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04610

Varga, E. A., & Moll, S. (2004). Cardiology patient pages. prothrombin 20210 mutation (factor II mutation). //Circulation//, 110(3), e15-e18. <span style="font-family: 'calibri','sans-serif'; font-size: 70%;"> Retrieved from @http://search.ebscohost.com.libproxy.unh.edu/login.aspx?direct=true&db=cmedm&AN=15262854&site=ehost-live

<span style="font-family: 'calibri','sans-serif'; font-size: 70%;">Wolberg, A. S., Monroe, D. M., Roberts, H. R., & Hoffman, M. (2003). Elevated prothrombin results in clots with an altered fiber structure: A possible mechanism <span style="font-family: 'calibri','sans-serif'; font-size: 70%;"> of the increased thrombotic risk//. Blood//, 101(8), 3008-3013. <span style="font-family: 'calibri','sans-serif'; font-size: 70%;"> Retrieved from @http://search.ebscohost.com.libproxy.unh.edu/login.aspx?direct=true&db=cmedm&AN=12506014&site=eds-live

** Web Resources ** The URLs for data presented herein are as follows: 23andMe __ [] __ OMIM [|http://omim.org/entry/176930#reference12] NCBI Protein [] dbSNP []

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