LMNA+Gene

LMNA GENE



 The LMNA gene codes for proteins Lamin A and Lamin C. LMNA (Fig. 1) is located on position 1q22 (q arm of human chromosome 1). The coding region of the LMNA gene is 24 kb long and contains 12 exons (OMIM). Both Lamin A and C belong to a larger family of proteins aptly named Lamins. Lamin proteins are a meshed network of intermediate components in the nuclear lamina which closely underly the inner nuclear membrane, providing its structure (OMIM, 2014). In addition to structure, they are involved in nuclear envelope stability and gene expression of most of our cells (except neurons which do not express LMNA). Mutations of the LMNA gene, in addition to HGPS and other forms of progeria, have been directly linked to other diseases like cardiomyopathy, Malouf syndrome, and four types of Muscular Dystrophy among others (OMIM, 2014).

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