Personal+Genomics+of+Alzheimer's+Disease+Results


 * 23andMe: **


 * Figure one shows the gene and SNP’s used by 23andMe to determine Alzheimer’s risk for its direct to consumer personal genomics testing. The figure shows results for a client based on the client’s genotype and adjusted odds ratio due to descent. In the provided results, the client has two copies of the ε3 allele based on her genotype at the tested SNPs (rs7412 and rs429358).


 * Figure two displays the SNPs used by 23andMe to determine the APOE variant alleles at both of the variant locations. These results are the basis for the company’s Alzheimer’s disease risk assessment. Those people with a thymine (T) nucleotide at location rs429358 and a thymine (T) base at rs7412 have the ε2 variant allele. Those with a thymine (T) nucleic acid at location rs429358 and a cytosine (C) at location rs7412 are said to have the ε3 allele. The ε4 APOE allele is determined by a cytosine (C) nucleotide at rs429358 and a cytosine (C) base at location rs7412.

**Ensemble: **
 * Figure three shows a karyotype of the human chromosomes. A karyotype is a graph which shows the number and appearance of chromosomes in the nucleus of a human cell. A visual representation of the location of the APOE gene is shown by the arrow in the figure. The APOE gene is found on the bottom half of chromosome nineteen.

**HapMap: **


 * Figure four shows a more detailed view of the location of the APOE gene on chromosome 19. The gene is found near the location 50M. This figure is used to gain a more clear understanding of the exact location of the APOE gene

**RCSB Protein Data Bank: **


 *  Figure five shows the structure of the ApoE3 protein.Included in the protein structure are eleven alpha helices and no beta sheets.It is a tertiary protein with only one protein forming its complete structure.

**Comparative Toxicogenomics: **




 * Figure six shows the top interacting chemicals that affect the APOE gene. These environmental factors may contribute to the formation of the APOE4 variant allele. The top interacting chemical listed on the Comparative Toxicogenomics Database page is tobacco smoke pollution, referenced by over 100 known interactions with the APOE gene. The interacting chemicals that follow tobacco smoke pollution for top interactions with the APOE gene are arsenic, dietary fats, dietary cholesterol and vehicle emissions.

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