Oxidative+Stress+Data+and+Results

Each different color ball shown above represents a protein kinase that is somehow related to the main kinase in question (OXSR1). OXSR1, which stands for Oxidative-Stress responsive, helps to regulate downstream kinases in response to any environmental stress related to oxygen. There is evidence here that shows it may have a function in assisting to regulate the actin cytoskeleton. OSR1 is a key enzyme in signaling the activity of Sodium, Potassium, and Chlorine transporters in response to osmotic stress. OSR1 have a carboxyl terminal that is conserved and recognizes a peptide (Arg-Phe-Xaa-Val). The results shown provide the first molecular look into the specific mechanism for which OSR1 kinase recognizes their activators and substrates.



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