AJT+The+Gene

=F2 Gene=

The gene that I have a SNP difference in is the F2 gene. This codes for coagulation factor II, Prothrombin. This glycoprotein is manufactured in the liver as an inactivated zymogen (enzyme that is not yet functional). When prothrombin is activated it becomes thrombin. Thrombin is an enzyme that converts fibrinogen to fibrin for clot formation, stimulates platelets to clump together at the wound site and activates a number of other coagulation factors including factors V, VIII and XIII.



The F2 gene resides on chromosome 11 on the P arm at 11.2. F2 is 20313 base pairs long (46740742 – 47671055). It contains 14 exons, and about 40% of the gene consists of 30 Alu repeats and two Kpn repeats. Alu & Kpn repeats are short sequences of DNA that are characterized by **Alu ** and Kpn restriction endonucleases.

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