Materials+and+Methods

This study brings together current research on genetically relevant pain pathways implicated in fibromyalgia, namely, the TRPV family of genes and, specifically, the TRPV1 gene and its expression as the TRPV1 channel.

In regards to fibromyalgia itself, general information about the syndrome, its prevalence, and current treatment protocols is taken from the **National Institutes of Health (NIH), the American College of Rheumatology (ACR),** and the **//National Fibromyalgia Association (NFA)//.**

Peer-reviewed journal articles provide information on current research into fibromyalgia and its genetic connection, notably with TRPV genes. See the link below for "Works Cited."


 * The Gene Cards: Human Gene Database** provides detailed information about the TRPV1 gene, its paralog genes, and its protein expression and pathways.

Current cyro-magnetic imaging has also been accessed for information about the structure and mechanisms of the TRPV channels. Three studies in particular have been referenced for the images they yielded:
 * Vera Y. Moiseenkova-Bell, V. Y, Stanciu, L. A., Serysheva, I. I., Tobe, B. J., & Wensel, T. G. (2008). Structure of TRPV1 channel revealed by electron cryomicroscopy. //Proceedings of the National Academy of Science in the United States.// 105 ( 21 ) 7451 - 7455 . doi: 10.1073/pnas.0711835105
 * Zheng J. (2013). Molecular Mechanism of TRP Channels. //Comprehensive Physiology//. 3(1):221-242. doi:10.1002/cphy.c120001
 * Liao M, Cao E, Julius D, Cheng Y. (20130) Structure of the TRPV1 ion channel determined by electron cryo-microscopy. //Nature//. 504(7478):107-112. doi:10.1038/nature12822.

Finally, the **Proove Genetic Test for Fibromyalgia** is presented as one way in which personal genomics is impacting the treatment of fibromyalgia’s painful symptoms. This test has been subject to some debate, the primary arguments of which will appear here, as well, under the link "Criticsm of the Proove Genetic Test."

Prevalence of Fibromyalgia TRPV Genes Family Portrait Imaging the TRPV1 Protein Channel Broader Impact - Pharmacogenetics and Fibromyalgia Criticism of the Proove Genetic Test Discussion - The Genetic Approach to Fibromyalgia Works Cited - Fibromyalgia