What+is+the+Role+of+TBX1

====TBX1 is a member of the T-box family of transcription factors that shares a common DNA-binding domain [8]. They are involved in regulating the developmental processes of tissues and organs during the embryonic development [5]. The T-box proteins bind to specific sections in the DNA to be able to perform its task in producing those genes required for normal development [6]. This gene has three isoforms, A, B, and C [8]. They all share exons 1-8 but they differ in the terminal exons 9A, 9B/10, and 9C [8]. Tbx1 is located in chromosome 22q11.21. To be precise, TBX1 is located from base pair 19,744,225 to base pair 19,771,115 on chromosome 22 [6].====

Tbx1 protein plays an important role for the normal development of the muscles and bones in the face and neck, heart arteries, ear structure and glands, such as thymus and parathyroid [6].
====Chen and colleagues discovered that the tissue regeneration was delayed when TBX1 was removed //in vivo// during homeostasis [5]. They concluded that TBX1 act as controller of BMP signals during stem cell quiescence and the hair follicle proliferation [5].====