AR+Locus

=The Androgen Receptor Gene Locus = The AR gene is located at Xq12: bp 66,763,873 to 66,944,118.

 http://useast.ensembl.org/Homo_sapiens/Location/View?db=core;r=X:66765127-66766127;source=dbSNP;v=rs6152;vdb=variation;vf=16128247;time=1323150116 Xq12 is indicated along the X chromosome with an arrow. The Xq12 region is then enlarged to show the region that encodes for the AR (indicated by the gold bar).

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Due to the AR gene being a large factor in the development of AGA, this gene's location on the X chromosome helps to explain the rumor of male pattern baldness skipping a generation when the father is affected. Males receive their X chromosome from their mother which means to predict if a male child is going to have AGA the child's mother is contributing one of the largest determining factors for AGA. The father has no influence over the AR gene so looking to the maternal grandparents and maternal siblings is a more effective way of prediction. ======

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*Reminder* As stated at the beginning of this wiki, AGA is a polygenic condition and risk factors have been located on several other chromosomes including chromosome 3q26 (6) and chromsome 20p11(8). These other factors are most likely responsible for the resemblance of father to son in balding patterns.(For the sake of this study the AR gene was identified as most important to explore.) ======

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 (6)Hillmer, A. M., Flaquer, A., Hanneken, S., Eigelshoven, S., Kortum, A.-K., Brockschmidt, F. F., Golla, A., Metzen, C., Thiele, H., Kolberg, S., Reinartz, R., Betz, R. C., Ruzicka, T., Hennies, H. C., Kruse, R., Nothen, M. M. Genome-wide scan and fine-mapping linkage study of **androgenetic** **alopecia** reveals a locus on chromosome 3q26. Am. J. Hum. Genet. 82: 737-743, 2008. ======

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 (8)Richards, J. B., Yuan, X., Geller, F., Waterworth, D., Bataille, V., Glass, D., Song, K., Waeber, G., Vollenweider, P., Aben, K. K. H., Kiemeney, L. A., Walters, B., and 10 others. Male-pattern baldness susceptibility locus at 20p11. Nature Genet. 40: 1282-1284, 2008. ======