MG+References

Works Cited Amur S, Parekh A, Mummaneni P. [|Sex differences and genomics in autoimmune diseases.] J Autoimmun. 2012 May;38(2-3):J254-65. doi: 10.1016/j.jaut.2011.12.001. Epub 2011 Dec 27. Review. PubMed PMID: 22204900.

Discover Magazine [|www.discovermagazine.com]“How a pit viper saved millions of lives: Snakes as drug factories” By [|Carl Zimmer]  | March 11, 2011 12:34 pm retrieved from []  accessed Dec 2013

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Gomez AM, Van Den Broeck J, Vrolix K, Janssen SP, Lemmens MA, Van Der Esch E, Duimel H, Frederik P, Molenaar PC, Martínez-Martínez P, De Baets MH, Losen M. [|Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction.] Autoimmunity. 2010 Aug;43(5-6):353-70. doi: 10.3109/08916930903555943. Review. PubMed PMID: 20380584.

Landouré G, Knight MA, Stanescu H, Taye AA, Shi Y, Diallo O, Johnson JO, Hernandez D, Traynor BJ, Biesecker LG; NIH Intramural Sequencing Center, Elkahloun A, Rinaldi C, Vincent A, Willcox N, Kleta R, Fischbeck KH, Burnett BG. [|A candidate gene for autoimmune myasthenia gravis.] Neurology. 2012 Jul 24;79(4):342-7. Epub 2012 Jun 27. PubMed PMID: 22744667; PubMed Central PMCID: PMC3400092.

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Pal J, Rozsa C, Komoly S, Illes Z. [|Clinical and biological heterogeneity of autoimmune myasthenia gravis.] J Neuroimmunol. 2011 Feb;231(1-2):43-54. doi: 10.1016/j.jneuroim.2010.10.020. Epub 2010 Nov 19. Review. PubMed PMID: 21093931.

Ramanujam R, Zhao Y, Pirskanen R, Hammarström L. [|Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity.] BMC Med Genet. 2010 Oct 13;11:147. doi: 10.1186/1471-2350-11-147. PubMed PMID: 20942939; PubMed Central PMCID: PMC2970590.

Soreq L, Gilboa-Geffen A, Berrih-Aknin S, Lacoste P, Darvasi A, Soreq E, Bergman H, Soreq H. [|Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays.] PLoS One. 2008 Jun 11;3(6):e2392. doi: 10.1371/journal.pone.0002392. PubMed PMID: 18545673; PubMed Central PMCID: PMC2409220.

<span style="font-family: 'Arial','sans-serif';">Tüzün E, Huda R, Christadoss P. [|Complement and cytokine based therapeutic strategies in myasthenia gravis.] J Autoimmun. 2011 Sep;37(2):136-43. doi: 10.1016/j.jaut.2011.05.006. Epub 2011 Jun 1. Review. PubMed PMID: 21636248.

<span style="font-family: 'Arial','sans-serif';">Viegas S, Jacobson L, Waters P, Cossins J, Jacob S, Leite MI, Webster R, Vincent A. [|Passive and active immunization models of MuSK-Ab positive myasthenia: electrophysiological evidence for pre and postsynaptic defects.] Exp Neurol. 2012 Apr;234(2):506-12. doi: 10.1016/j.expneurol.2012.01.025. Epub 2012 Feb 3. PubMed PMID: 22326541.

<span style="font-family: 'Arial','sans-serif';">Zisimopoulou P, Brenner T, Trakas N, Tzartos SJ. [|Serological diagnostics in myasthenia gravis based on novel assays and recently identified antigens.] Autoimmun Rev. 2013 Jul;12(9):924-30. doi: 10.1016/j.autrev.2013.03.002. Epub 2013 Mar 26. PubMed PMID: 23537507.

<span style="color: #ff0000; font-family: Arial,Helvetica,sans-serif;">Genomics and Bioinformatic References <span style="font-family: 'Arial','sans-serif';"> **National Center for Biotechnology Information (NCBI**) [] <span style="font-family: 'Arial','sans-serif';">US national resource for molecular biology information, linking public databases.

<span style="font-family: 'Arial','sans-serif';">**<span style="font-family: 'Arial','sans-serif';">Molecule Evolutionary Genetic Analysis (MEGA) **[|www.megasoftware.net/] Phylogenetic and molecular evolutionary analyses were conducted using MEGA version 5 (Tamura, Peterson, Stecher, Nei, and Kumar 2011) <span style="font-family: 'Arial','sans-serif';">MEGA is an integrated tool for conducting sequence alignments and inferring phylogenetic trees by reconstructing the evolutionary histories for a given specie. Used to investigate if the MuSK gene is conserved in other species.

<span style="font-family: 'Arial','sans-serif';">**STRING 9.05** [] <span style="font-family: 'Arial','sans-serif';">STRING is a database which uses known and predicted interactions between proteins. It uses physical and functional groupings. The site takes these associations and uses algorithms to relate them to other organisms. This site gives a good visual representation of genes and proteins working together.

<span style="font-family: 'Arial','sans-serif';">**Tree Families** Database (TreeFam) [] <span style="font-family: 'Arial','sans-serif';">TreeBest (1) Ruan,J., Li,H., Chen,Z., Coghlan,A., Coin,L.J.M., Guo,Y., Hériché,J.-K., Hu,Y., Kristiansen,K., Li,R., et al. (2008) TreeFam: 2008 Update. Nucleic Acids Res, 36, D735-40. Found at [|http://www.treefam.org/family/TF106465#tabview=tab1] accessed Dec 2013 <span style="font-family: 'Arial','sans-serif';">(2) Guindon,S., Dufayard,J.-F., Lefort,V., Anisimova,M., Hordijk,W. and Gascuel,O. (2010) New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol, 59, 307-321. <span style="font-family: 'Arial','sans-serif';">The tree families database uses its ortholog database to use evolutionary events (duplications of genes, creation of new species and losses events) to build phylogenetic trees of animal genes. This site compares a family of gene types to particular species. Myasthenia gravis Home