Methods+and+Data

= Methods Used =

The following are the genes and proteins that were investigated in this study:
 * **ApoE Gene** || **ApoE Proteins** ||
 * Homo sapiens (Human) NG_007084.2 || Homo sapiens (Human) AAB59518.1 ||
 * Cercopithecus aethiops (Grivet) AY738150.1 || Gorilla gorilla (Western Gorilla) Q9GLM8.1 ||
 * Pan troglodytes (Chimpanzee) NM_001009007.1 || Papio anubis (Olive Baboon) XP_003918648.1 ||
 * Papio Anubis (Olive Baboon) XM_003918602.1 || Macaca fasccularis (Crab-eating macaque) P10517.1 ||
 * Macaca fascicularis (Crab-eating macaque) X13887.1 || Otolemur garnettii (Northern Greater Galago) XP_003799545.1 ||
 * Nomasus leucogenys (Northen White-cheeked Gibbon) XM_004091027.1 || Bos Taurus (Cattle) NP_776416.1 ||
 * <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Trichechus manatus latirostris (Florida Manatee) XM_004444152.1 || <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Sus scrofa (Wild Boar) AAC29512.1 ||
 * <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Canis lupis familiaris (Dog) NC_006583.3 || <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Pan troglodytes (Chimpanzee) NP_001009007.1 ||
 * <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Sus scrofa (Wild Boar) NC_010448.3 || <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Mus musculus (House Mouse) CAJ18420.1 ||
 * <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Bos Taurus (Cattle) XM_005219150.1 || <span style="display: block; font-family: Arial,Helvetica,sans-serif; text-align: center;">Hylobates lar (Lar Gibbon) Q9GLM6.1 ||

Investigation Tools Used:

 * 1) ====BLAST: This tool could be used to see if any other species share the same or similar genes that are related to Alzheimer’s and if it serves the same function in that species as in humans. The genes that would be search for are ApoE, APP, PS1, PS2, SPON1, and CRR2.====
 * 2) ==== MEGA: This tool will be used to see the phylogenetic tree of humans and how closely related to other species humans are and based on this, the most closely related species can be looked at to see if they share the same genes that cause Alzheimer’s in humans. ====
 * 3) ====KEGG: This tool will be used to determine what drugs are used to treat Alzheimer's disease and what part of the biological system they target.====
 * 4) ====Gene Ontology: This tool will be used to find the ontology for the ApoE gene. A Gene's ontology is made up the biological processes it is involved in along with the cellular components it is present in and the molecular functions it has. This will help determine what might be affected if the ApoE gene is mutated.====

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