Methods&MaterialsSCD

Methods and Materials
 * Looked for articles on genomic information using the school's research data bases (Early February, 2016)
 * Specifically, looked up sickle cell disease and narrows results down to the last 6 years and only viewed reviewed articles
 * Used a direct to consumer website for information on genomic testing (February 2016)
 * 23andMe (https://www.23andme.com/)
 * Gene Tested for Sick Cell: Hb S (also referred to Hb SS)
 * In order to gain access to this information, one must have access to an account of one's
 * In the results section under inherited conditions, there is a list of inherited conditions and sickle cell is among them [[image:prescottgenomics/analysisimage.jpg align="right"]]
 * The Sickle Cell Testing results are in there as well as brief information on the causes and affects of Sickle Cell.
 * Searched for information from free genetic data offering websites (February-March 2016)
 * Genetic Testing Registry ( http://www.ncbi.nlm.nih.gov/gtr/ )
 * Tests Available for detection of genes responsible for SCD
 * Without any filters, searched "sickle cell disease" and several results, the 1st being Hb SS disease. Clicking that link leads to a list of tests that detect sickle cell
 * Ensemble ( http://www.ensembl.org/Homo_sapiens/Variation/Explore?db=core;ph=17912;r=11:5007973-5008973;v=rs2445284;vdb=variation;vf=1802079 )
 * Variants of Hb SS
 * SearchedSickle Cell anemia for only humans to find out what variant occur and found information on populations affected or more susceptible to be affected.
 * SNP rs2445284 was looked into and the population genomics information came from it
 * Hapmap (http://hapmap.ncbi.nlm.nih.gov/cgi-perl/gbrowse/hapmap3r3_B36/#search)
 * Searching HBB, the image of chromosome 11 where the HBB gene is found is observed.
 * HDGP Selection Browser (http://hgdp.uchicago.edu/cgi-bin/gbrowse/HGDP/)
 * searching HBB gene weilds images of the 11th chromosome and more information on that particular gene and its variants
 * Looked for pharmaceutical correlations with the disease (March 2016)
 * PharmGKB ( https://www.pharmgkb.org/disease/PA443355?previousQuery=%22Sickle%20cell%20anaemia%22#tabview=tab0&subtab=31)
 * Sickle cell anemia was plugged in to the search bar and from the results, the Sickle cell anemia topic was chosen.
 * DrugBank([] )
 * Searching sickle cell anemia under the drugs category, drugs that were approved were recovered form the list of results and looked into.
 * Google searched the history of sickle cell disease and sickle cell disease organizations (March 2016)

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