AGA+Discussion

=Looking toward the future of AGA = Now that researchers are identifying more and more susceptibility loci and honing in on the AGA mutation within the androgen receptor's code we should develop new understanding on ways to prevent this condition. We should then be able to apply our new understanding in the form of medication that we can test on our new mouse model. Hopefully, the next round of drugs will be able to target the mutation in the receptor instead of the hormones (Testosterone or DHT) to avoid the prostate cancer increase and unwanted sexual side effects. Overall, it looks like our understanding and treatment of AGA is headed in the right direction.

=__**Genomic and Bioinformatic tools used in this wiki**__ =

http://useast.ensembl.org/index.html

This site was used to locate and show the locus of the androgen receptor gene within chromosome X. It also was used to identify what the nucleotide change was in the rs 6152 SNP.

--Kegg Pathways--
http://www.genome.jp/kegg/kegg2.html

This site was used to locate the enzyme and products targeted by the 5-alpha-reductase inhibitor class of medications and to display where this reaction occurs in the steroid hormone biosynthesis pathway.

--M.E.G.A.--
http://www.megasoftware.net/ This tool was used to align mRNA sequence data for several organisms and create a phylogenetic tree that showed sequence relationships.

--USMC Genome Browser--
http://genome.ucsc.edu/index.html?org=Human&db=hg19&hgsid=226891499 This tool was used to find and display SNPs upstream from the rs 6152 SNP that could possibly have linkage disequilibrium.

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References

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