PKU+Materials+and+Methods

https://www.23andme.com/en-ca/health/Phenylketonuria/
 * __ 23andMe: __**

Accessed between February and May 2016

This method presented the disease and the variants of the gene PAH from participants. 23andMe is a good website for obtaining the connections between genes and variants associated with those genes. It can also be informative about the history and ancestry behind the risk for PKU.

-Access 23andMe Canada website -Search for PKU in the search bar -Select 23andMe Canada - A List of All Health Reports -View Inherited Conditions and find PAH gene, with Phenylketonuria as the condition

http://string-db.org/cgi/network.pl?taskId=pP6TvNW8khs6 Accessed April 2016
 * __ STRING: __**

This method presented the protein connections between PAH and other proteins. The more connections between other genes, the stronger the correlation between that gene and PKU.

-Access STRING website -Search for PAH gene/protein -Make sure only Homo Sapiens is selected and click continue

__**GWAS: **__ http://www.gwascentral.org/generegion/markers?q=PAH&t=3&vt=all&l=asd&page=1&format=html Accessed May 2016

This method displays correlations between diseases and phenotypes, SNPs/markers on the gene of interest, studies done about the gene of interest and the location of the gene.

-Access GWAS central website -Search PAH in the gene/region tab -select the 6 markers tab for the SNPs

Next-Results Home PAH Gene Current Research Discussion References