CAD+-+Discussion

The species analyzed for the CDKN2A gene resulted in significant nucleotide and protein alignment. The protein and nucleotide trees are almost identical indicating that the expected protein sequence relates the organisms similarly to the nucleotide sequence. In the phylogenetic trees it is evident that some species have similar nucleotide sequences in this gene region. The brown rat and house mouse are closely related and likely some of the earliest organisms to evolve this gene. Human, gorilla, and chimpanzee are also share similar CDKN2A structure. This is expected as we know that these species are all very closely related from an evolutionary standpoint. The cat, cow, and opossum are not as closely related but are located on the same branch. When evaluating the STRING protein interactions there are many important relationships to other functions such as tumor suppressor genes (Zhuang, 2012). The structure of the protein Cdk6-p16ink4a that was developed using NCBI Structure is interesting. This is one of the primary proteins involved with the CDKN2A gene.
 * Data Analysis**

Coronary artery disease has many contributing factors. Genetic variants are now known to be a major cause of CAD. CDKN2A is one gene that has variations which increase the risk of CAD. The gene is well preserved across species with similarity in both nucleotide and protein sequences. Further research on this topic will lead to a better understanding of the genetic causes of CAD. There is a vast amount of research that has already been performed on the topic but there will undoubtedly be further genetic links discovered.
 * Conclusion**

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Introduction Primary Research Methods Data and Results References