Genomics+and+Bioinformatics+Tools

In order to determine which model organism is helpful to study for a specific genetic disease, a phylogenetic tree is used. A phylogenetic tree is a diagram that uses branches to show the evolutionary relationship of different species based on its genetic similarities and differences.

BLAST Phylogenetic trees were computed using default parameters in MEGA and 500 bootstrap replicates were conducted for each computation. All phylogenetic trees made from the MEGA program were from the BLASTn of MuSK protein (accession number NM_001166280.1) and were PREDICTED results. The following sequences were used:



This is the alignment of the MuSK gene using MEGA:

MEGA This is the MuSK gene represented by a phylogenetic tree:



This is the MuSK protein alignment:

MuSK protein minimum evolution phylogenetic tree: 

STRING STRING is a database which uses known and predicted interactions between proteins. It uses physical and functional groupings. The site takes these associations and uses algorithms to relate them to other organisms. This site gives a good visual representation of genes and proteins working together.

From STRING, this is the Action View of the MuSK protein (accession number NM_001166280.1).



TreeFam

 The tree families database uses its ortholog database to use evolutionary events (duplications of genes, creation of new species and losses events) to build phylogenetic trees of animal genes. This site compares a family of gene types to particular species.



Myasthenia gravis Home

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