Gaucher+3

To further investigate the GBA gene a phylogenetic tree was generated using the database MEGA 5. From this, evolutionary relationships between species, their common ancestry and how their genes are conserved could be analyzed. To do this, a BLASTp was performed on five different species for and their Glucosidase, beta, acid gene in the program Geneious. Once a batch export transferred the sequences to MEGA it was aligned by clustal W. Unable to put the common names in place on the tree or Clustal W alignment, the sequences are as follows: GBA- 2629: Homo sapiens or Humans GBA- 14466: Mus musculus or Mouse GBA- 449571: Pan troglodyes or Chimpanzee GBA- 612206: __#|Canis lupus__ familiaris or Dog GBA- 684536: Rattus norvegicus or Rat GBA- 100399524: Callithrix jaccus or New World Monkey
 * Phylogenetic Tree **



This Maximum Likelihood phylogenetic tree was constructed using a bootstrap analysis. For a tree to be reliable the bootstrap values must be at least 70. This phylogenetic tree shows the relationship between human GBA genes and the mouse is much closer is common, than the other chosen species indicating common ancestry between the two. The bootstrap value was not shown but was 86, which is proven reliable.

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