Amir Parajuli
aba42@wildcats.unh.edu
University of New Hampshire
Biomedical Sciences

Abstract:
The goal of this research is to gain further understanding of prostate cancer. Moreover, understanding which gene play key roles in development of prostate cancer. In this research, the gene that were primarily focused is HOXB13 gene. Results from various research show that there is an early risk of developing prostate cancer with stronger association of HOXB13 gene. However, there still needs further research to gain full understanding of this cancer.


public domain image.jpg
Swelling of the prostate. *Image obtained from public google domain with usage rights




Introduction:
Prostate cancer is the second most commonly diagnosed cancer among men. Prostate cancer develops in the prostate gland when cells begin to grow wildly. According to Prostate Cancer Health Center, symptoms can include frequent urinating, blood in urine, painful during urination and weak or interrupted urinary stream.

Early detection of prostate cancer can be often found by testing prostate-specific antigen (PSA) in male’s blood but elevated PSA levels doesn’t always indicate cancer. When surgery is performed through radiation and surgery, there are side effects that can affect quality of life. There is another way by the method of digital rectal exam (DRE) which is more painful than the first. One concerning fact is that neither of these tests are 100% accurate.

Family history is also common factor of prostate cancer. First degree relatives are 2.48 more likely to develop prostate cancer. 1 in 6 men will be diagnosed with prostate cancer in their lifetime. Therefore, understanding gene expression in genetics is very important in controlling and finding a cure for this cancer.


Research Questions:
1.What is the relationship of this gene comparing humans with other species at DNA level?
2.What other genes could be affcted by the mutation in HOXB13?
















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