Does the linked colon cancer gene PTPRJ have any genomic implications in other organisms?

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PTPRJ protein quaternary structure Public Domain no permission required for replication of image

Genomics, Proteomics and Bioinformatics Fall 2010

PTPRJ Background Information and recent groundbreaking developments
Applied Genomic Tools Used to Inquire about Hypothesis

~ Locate this Gene Using Map Viewer................. PTPRJ Mapviewer

~ Protein Algorithm Analysis Using BLASTp Program....... PTPRJ BLASTp Program

~ Alignment Using Geneious...................... PTPRJ Alignment

~ Phylogenetic Trees & Bootstrap Analysis Using MEGA 5 Beta 4.......... PTPRJ Phylogenetic Trees

Annotated Bibliography

  • 1. Endocrinology Iuliano R, Palmieri D, He H, Iervolino A, Borbone E, Pallante P, Cianflone A, Nagy R, Alder H, Calin GA, Trapasso F, Giordano C, Croce CM, de la Chapelle A,Fusco A. (2010). Role of PTPRJ genotype in papillary thyroid carcinoma risk. Endocrine-Related Cancer.17(4):1001-6. This article was used to establish supporting evidence of PTPRJ in connection with thyroid carcinoma.

  • 2. Oncogenetics Ruivenkamp, C., et al (2003). LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12–21. Oncogene; Division of Molecular Genetics. 22, 3472-3474. This article was used to collect information that supported the hypothesis that PTPRJ was a predictor of colorectal cancer.

  • 3. Entrez Gene Official Symbol: PTPRJ and Name: protein tyrosine phosphatase, receptor type, J[Homo sapiens] Other Aliases: CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
    Other Designations: CD148 antigen; DEP-1; HPTP eta; R-PTP-J; density-enhanced phosphatase 1; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; protein-tyrosine phosphatase receptor type J; receptor-type tyrosine-protein phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of Chromosome: 11; Location: 11p11.2 Annotation: Chromosome 11NC_000011.9 (48002110..48192394) MIM: 600925 ID: 5795
    This article was used to gather summary gene and lineage information on PTPRJ.

Genomics Tools Bibliography